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Референтни граници на БФАГ за церебро-плацентарното съотношение (Cerebroplacental ratio – CPR) в българската популация

П. Игнатов, З. Богословова, Т. Йорданова.  (2025). Референтни граници на БФАГ за церебро-плацентарното съотношение (Cerebroplacental ratio – CPR) в българската популация. 1(10). doi: 10.70926/FMOG/1/2025.0002.CPR.1.10.

        English abstract available

79c3beb019531a46bcc6db7 20250224204956296 info@orthogyn.com:bfog ignatov@orthogyn.com WEB-FORM Fetal Medicine, Obstetrics and Gynecology FMOG 30331250 10.70926/FMOG https://bfag.bg/journal/ 02 24 2025 1 10.70926/FMOG/1 https://bfag.bg/journal Bulgarian Federation of Obstetrics and Gynecology (BFOG) reference ranges for the Cerebroplacental ratio (CPR) Референтни граници на БФАГ за церебро-плацентарното съотношение (Cerebroplacental ratio – CPR) в българската популация Orthogyn Medical Center Petar Ignatov https://orcid.org/0000-0003-1656-5316 Teodora Yordanova-Ignatova https://orcid.org/0000-0003-0653-7370 Introduction: The aim of this study is to establish reference ranges for the cerebroplacental ratio (CPR). This is motivated by two key factors. First, there is a wide variety of similar studies in the scientific literature, but the data presented in them have been processed using very different statistical approaches. This makes comparison between studies challenging and, in some cases, even impossible. Second, and no less important, some existing nomograms combine highly heterogeneous populations, often including different countries and even continents. Others focus on relatively homogeneous cohorts from smaller geographical regions, which, however, are not sufficiently close to our country to be used as a representative sample for Bulgaria. Materials and Methods: To establish the proposed reference ranges for CPR, we conducted a prospective observational study between 2022 and 2024, covering 834 singleton pregnancies between the 28th and 40th gestational weeks. All pregnancies were dated using last menstrual period (LMP) and/or ultrasound measurement of the crown-rump length (CRL) in the first trimester. Pregnancies with complications, fetal anomalies, and multiple gestations were excluded. Doppler measurements were performed by certified specialists according to a standardized protocol. For each gestational week, we calculated the median, 5th, and 95th percentiles. Results: Based on the collected data, we developed reference ranges for CPR in the Bulgarian population. Comparative analysis with other nomograms revealed significant differences in numerical values across different gestational weeks. Conclusions: To the best of our knowledge, this is the first and currently the only study in Bulgaria that provides reference charts for CPR based on the latest standardized protocols for processing such data. The availability of precisely constructed reference ranges for CPR, reflecting the characteristics of the local population, is a key prerequisite for reducing morbidity and mortality in the early neonatal period, particularly in pregnancies with early-onset fetal growth restriction. 02 24 2025 10.70926/FMOG/1/2025.0002.CPR.1.10 https://bfag.bg/2025/02/24/cpr/